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Test Code | Test Name | Turnaround | Blood Sample | Tissue Sample | CPT Codes 2015 | CPT Codes 2013 |
---|---|---|---|---|---|---|
8003 | VSX1 (Visual System Homeobox 1) | 3 weeks | $800.00 | $900.00 | 81404 | 81479 |
The VSX1 gene encodes a pair-like homeodomain and regulates many genes’ expression in the eyes[3]. Mutations of this gene can cause keratoconus and posterior polymorphous corneal dystrophy [2], another type of corneal dystrophy. In this test, genomic DNA will be purified from a biological sample and used for PCR. 6 sets of exon-specific primers will be used to amplify the exons and the exon-intron junctions for this gene.
2. Heon, E., et al., VSX1: a gene for posterior polymorphous dystrophy and keratoconus. Hum Mol Genet, 2002. 11(9): p. 1029-36.
3. Semina, E.V., H.A. Mintz-Hittner, and J.C. Murray, Isolation and characterization of a novel human paired-like homeodomain-containing transcription factor gene, VSX1, expressed in ocular tissues. Genomics, 2000. 63(2): p. 289-93